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KMID : 0624620120450050305
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BMB Reports
2012 Volume.45 No. 5 p.305 ~ p.310
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Replication of genome-wide association studies on asthma and allergic diseases in Korean adult population
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Yoon Dan-Kyu
Ban Hyo-Jeong
Kim Young-Jin
Kim Eun-Jin
Kim Hyung-Cheol
Han Bok-Ghee
Park Jung-Tak
Hong Soo-Jong
Cho Sang-Heon
Park Kie-Jung
Lee Joo-Shil
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Abstract
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Allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis are heterogeneous diseases characterized by multiple symptoms and phenotypes. Recent advancements in genetic study enabled us to identify disease associated genetic factors. Numerous genome-wide association studies (GWAS) have revealed multiple associated loci for allergic diseases. However, the majority of previous studies have been conducted in populations of European ancestry. Moreover, the associations of single nucleotide polymorphisms (SNPs) with allergic diseases have not been studied amongst the large-scale general Korean population. Herein, we performed the replication study to validate the previous variants, known to be associated with allergic diseases, in the Korean population. In this study, we categorized three allergic related phenotypes, one allergy and two asthma related phenotypes, based on self-reports of physician diagnosis and their symptoms from 8,842 samples. As a result, we found nominally significant associations of 6 SNPs with at least one allergic related phenotype in the Korean population.
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KEYWORD
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Allergic diseases, Asthma, GWAS replication, Korean
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